Published by INIA.
Yes—INFUSE+ is designed to help compatible serum ingredients move beyond the skin's surface more effectively than hand application alone. It uses brief electrical pulses, called electroporation, to temporarily make the outer skin barrier more permeable. How deep an ingredient goes still depends on the ingredient, the complete formula, and the treatment conditions.
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What INFUSE+ Changes After You Apply Serum
Hand application spreads serum across the skin's surface. The outer skin barrier is designed to keep many outside substances from moving farther, so simply applying a thicker layer does not guarantee deeper delivery.
INFUSE+ adds a different step. Its brief electrical pulses temporarily increase skin permeability, creating short-lived pathways through the barrier. While a compatible serum is present, its ingredients can move into the skin more effectively than with surface application alone.
See SPHERA INFUSE+ in Use
Watch what INFUSE+ adds after serum
TJ explains electroporation at 1:39 and demonstrates the serum step at 12:12. During the test period, TJ paired INFUSE+ with richer hydrating and peptide-focused serums and later described skin that felt more hydrated and looked plumper.
These are TJ's personal observations. The video description includes affiliate links and a discount code; the creator may earn a commission.
What Does the Research Actually Show?
Electroporation is not a beauty-marketing invention. It is an established delivery principle studied in cell membranes, skin models, and drug delivery research. The strongest evidence supports the mechanism; it does not make every serum or every device interchangeable.
1993 PNAS skin study
Electrical pulses increased transport across mammalian skin for the polar molecules tested. Why it matters: skin electroporation is a real delivery mechanism, not simply a massage effect.
2000 macromolecule study
Under the studied protocol, transport increased for fluorescent model molecules from 4.4 to 38 kDa. Why it matters: some larger molecules can benefit under controlled conditions, but size alone does not predict every serum's result.
2024 delivery study
Delivery behavior changed with the electrical conditions and the size and charge of the test molecule. Why it matters: the device, ingredient, formula, and skin model all affect the result.
A major review in Nature Reviews Drug Discovery likewise describes electroporation as brief electrical pulses that create short-lived pathways and support transport through skin. Taken together, the research supports electroporation as a delivery principle—not a promise that every ingredient reaches the same layer.
What Does "Deeper Serum Absorption" Mean Here?
Here, "deeper" means helping suitable ingredients move into the skin more effectively than when they are left on the surface. It does not mean a fixed number of millimeters, and it does not mean that every ingredient reaches the dermis or enters the bloodstream.
Research distinguishes between entering the outer skin, being retained in a particular skin layer, and passing all the way through the skin. Those are different outcomes. SPHERA's practical promise is supported topical delivery, not injection or systemic delivery.
Which Serum Should You Use With INFUSE+?
Start with a familiar water-based serum, essence, or cream that is meant to stay on the face and gives the treatment head enough slip to keep moving. You do not need an INIA-branded serum, but the complete formula still needs to suit your skin and the mode.
Simple water-based hydration
Begin with a hydrating serum or essence you already tolerate well. This gives the device slip without adding several strong actives at once.
PDRN, peptides, and hyaluronic acid
TJ used products in these categories. That is a routine example, not proof that every formula with the same hero ingredient behaves identically.
Strong actives and pure oils
Do not use deeper delivery as a reason to intensify an irritating formula. Pure oils are not the default pairing because current guidance specifies water-based skincare.
For a more detailed formula-selection guide, see what to use with electroporation at home. Texture, price, and a single hero ingredient are not compatibility tests; when in doubt, check the complete product directions before pairing it with an electrical skincare device.
How to Use SPHERA INFUSE+ With Serum
INFUSE+ can be selected independently; you do not need to run all five SPHERA modes first. Apply skincare before switching on the mode.
The five-minute timer pauses if skin contact is lost, so keep the treatment head flat rather than hovering. Current SPHERA guidance allows INFUSE+ to be used daily or whenever needed, but that does not override the frequency directions for the serum itself. Clean the treatment head after use.
For the controls, treatment areas, and preparation required by the other four modes, see the complete INIA SPHERA how-to guide.
Who Gets the Most Value From INFUSE+?
INFUSE+ makes the most sense if serum is already an important part of your routine: you regularly use compatible hydrating or treatment formulas, want them to move beyond surface application, or dislike leaving a richer product sitting on top of the skin.
It is less compelling as a purchase reason if you rarely use serum, prefer oil-first routines, or already own an electroporation device you use consistently. When a viewer asked whether electroporation alone was a reason to upgrade, TJ did not recommend replacing a device that already met that need. INFUSE+ is valuable when it solves a gap you actually have.
Serum First. INFUSE+ Next.
INFUSE+ turns serum application into a dedicated delivery step. Use it with compatible water-based skincare when helping ingredients move beyond the surface is a result you will actually value.
Frequently Asked Questions
Can I use any serum with SPHERA INFUSE+?
No. Start with compatible water-based skincare that is intended to remain on the face and provides enough slip for continuous movement. Your skin tolerance and the complete formula matter; do not judge compatibility only by price, thickness, or one featured ingredient.
Can INFUSE+ help with larger ingredients such as peptides, PDRN, or hyaluronic acid?
Electroporation research has increased the skin transport of some model macromolecules under controlled conditions, so the scientific principle is relevant to larger ingredients. But peptides, PDRN, and hyaluronic acid vary in size, charge, structure, and formulation. Their ingredient names alone cannot tell you how deeply a particular finished serum will travel.
Does "deeper absorption" mean the serum enters the bloodstream?
No—that is not the intended or claimed endpoint of INFUSE+. Here, "deeper" means supporting delivery into the skin beyond surface application, not systemic delivery.
How is SPHERA INFUSE+ different from FLARE's infusion mode?
FLARE uses iontophoresis, which mainly relies on electrical charge to move suitable charged ingredients. SPHERA INFUSE+ uses electroporation to temporarily increase skin permeability, so it is designed to support a broader range of compatible water-based skincare ingredients.
Can I use INFUSE+ every day?
Current SPHERA guidance says INFUSE+ can be used daily or whenever needed. The formula paired with it may have its own frequency limits, especially if it contains retinoids, acids, or other strong actives.
